Protein Biomarkers in Cancers of the Digestive Tract - a Step Towards Personalized Medicine

Author(s): Erno Duda, Elena Codrici, Daniela Ionela Popescu, Laura Necula and Radu AlbulescuPages 228-236 (9) Abstract: Digestive tract cancers – gastric-, colorectal-, pancreatic-, hepatocarcinoma- and esophageal are some of the most frequent cancers; they are characterized by invasivity, metastatic potential and bad outcomes. This group includes several of the most critical cancers (those ranked 2nd-4th in cancer related mortality), and,...

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Anti-cancer Therapies in High Grade Gliomas

Author(s): Cristiana Pistol Tanase, Ana-Maria Enciu, Simona Mihai, Ana Iulia Neagu, Bogdan Calenic and Maria Linda CruceruPages 246-260 (15) Abstract: High grade gliomas represent one of the most aggressive and treatment-resistant types of human cancer, with only 1–2 years median survival rate for patients with grade IV glioma. The treatment of glioblastoma is a considerable therapeutic challenge; combination therapy targeting multiple pathways...

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A Simple Protein Extraction Method for Proteomic Analysis of Diverse Biological Specimens

Author(s): Panga Jaipal Reddy, Aishwarya Anand Rao, Darpan Malhotra, Samridhi Sharma, Ravinder Kumar, Rekha Jain, Kishore Gollapalli, Namita Pendharkar, Srikanth Rapole and Sanjeeva SrivastavaPages 298-311 (14) Abstract: The success of a proteomic experiment largely depends on the quality and quantity of the protein extract. Currently, various protocols are available for extraction of proteins from different types of samples; however, further...

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Important Anti-Cancer Applications of Protein Based Nanoparticles

Author(s): Mustafa Ergul, Merve Ergul and Yusuf TutarPages 334-340 (7) Abstract: Cancer is one of the most important health problems in the world and the treatment approaches are still challenging and generally not at desirable levels. Conventional anti-cancer agents may cause systemic toxicity, have poor solubility, and lack of selectivity. In order to overcome these hurdles, nanoparticle based therapeutics have been widely employed to enhance...

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B-factor Analysis and Conformational Rearrangement of Aldose Reductase

Author(s): Ganesaratnam K. Balendiran, J. Rajendran Pandian, Evin Drake, Anubhav Vinayak, Malkhey Verma and Duilio CascioPages 151-160 (10) Abstract: The NADPH-dependent reduction of glucose reaction that is catalyzed by Aldose Reductase (AR) follows a sequential ordered kinetic mechanism in which the co-factor NADPH binds to the enzyme prior to the aldehyde substrate....

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